Cannabis and Cannabinoid Research (2021)
Cannabis sativa as a Treatment for Obesity: From Anti-Inflammatory Indirect Support to a Promising Metabolic Re-Establishment Target
Eulla Keimili Fernandes Ferreira Cavalheiro, Ana Beatriz Costa, Daniéle Hendler Salla, Mariella Reinol da Silva, Talita Farias Mendes, Larissa Espindola da Silva, Cristini da Rosa Turatti, Rafael Mariano de Bitencourt, and Gislaine Tezza Rezin
Obesity is defined as an excess of accumulation of fat that can be harmful to health. Storage of excess fat in the adipose tissue triggers an inflammatory process, which makes obesity a low-grade chronic inflammatory disease. Obesity is considered a complex and multifactorial disease; hence, no intervention strategy appears to be an ideal treatment for all individuals. Therefore, new therapeutic alternatives are often studied for the treatment of this disease. Currently, herbal medicines are gaining ground in the treatment of obesity and its comorbidities. In this context, much attention is being paid to Cannabis sativa derivatives, and their therapeutic functions are being widely studied, including in treating obesity.